ABSTRACT
Crohn's disease is an inflammatory bowel disease characterized by remissions and exacerbations. Immunosuppressants are frequently used to induce and maintain remission in these patients. The use of the immunomodulator azathioprine has been associated to malignancies. Chordomas are rare, locally aggressive tumors arising from remnants of the notochord. A specific trigger for this tumor has not been identified and association to any medication has not been reported. The purpose of this report is to present the first case reported in the literature of Crohn's disease associated to a chordoma. The patient to be presented was on azathioprine therapy, among other medications. A review of literature revealed that Crohn's disease and chordoma have abnormalities in chromosomes 1 and 10. Inflammatory bowel disease and chordoma also have abnormalities in chromosomal regions 1p, 3p, and 7q. Despite these findings, a direct genetic relationship between these diseases is speculative.
Subject(s)
Humans , Female , Adult , Chordoma/complications , Crohn Disease/complications , Skull Base Neoplasms/complications , Chordoma/diagnosis , Chordoma/surgery , Crohn Disease/drug therapy , Crohn Disease/pathology , Immunosuppressive Agents/therapeutic use , Magnetic Resonance Imaging , Neurosurgical Procedures , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/surgery , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Extreme lateral lumbar disc herniation is located in the foramen and compresses the exiting root producing symptoms attributed to the upper nerve root of the involved disc and vertebral level. The diagnosis is best established by using magnetic resonance imaging which visualizes the foramen in an axial and sagittal plane. Surgical treatment may be varied, but a posterior midline approach with drilling of the pars interarticularis will easily expose the nerve root and the herniated disc in the foramen. Results are usually excellent, with resolution of radicular pain
Subject(s)
Humans , Female , Middle Aged , Intervertebral Disc Displacement/diagnosis , Intervertebral Disc Displacement/surgery , Lumbar Vertebrae , Diagnostic ImagingABSTRACT
A case of a thoracic osteochondroma with compression of the spinal cord is reported. The neuroimaging studies are described
Subject(s)
Humans , Female , Adult , Spinal Cord Compression/etiology , Spinal Neoplasms/complications , Osteochondroma/complications , Paraplegia/etiology , Thoracic Vertebrae , Spinal Cord Compression/diagnosis , Spinal Cord Compression , Follow-Up Studies , Magnetic Resonance Imaging , Spinal Neoplasms/diagnosis , Spinal Neoplasms/surgery , Osteochondroma/diagnosis , Osteochondroma/surgery , Time Factors , Thoracic VertebraeABSTRACT
A unique case of cerebral toxoplasmosis which had an acute appearance of multiple discrete lesions following a biopsy and its neuroradiological findings are reported in detail. Possible pathophysiological mechanism are presented